【药物名称】Flupirtine maleate, D-9998, Katadolon
化学结构式(Chemical Structure):
参考文献No.53539
标题:Flupirtine
作者:Casta馿r, J.; Serradell, M.N.; Blancafort, P.
来源:Drugs Fut 1983,8(9),773
合成路线图解说明:

The reaction of 2,6-dichloro-3-nitropyridine (I) with ammonia yields 2-amino-3-nitro-chloropyridine (II). 4-Fluorobenzylamine (III) reacts in dioxane and in the presence of triethylamine with (II), resulting in the 2-amino-3-nitro-6-p-fluorobenzylamine derivative (IV). The latter is hydrated and in situ the 3-amino group is condensed with ethyl chloroformate leading to the stable 2-amino-3-carbethoxyamino-6-(p-fluorobenzylamino)pyridine (Flupirtine).

参考文献No.700765
标题:
作者:Thiele, K.; Steinmetz, G.; Bebenburg, W.v.
来源:Chem Ztg 1979,103(10),387
合成路线图解说明:

The reaction of 2,6-dichloro-3-nitropyridine (I) with ammonia yields 2-amino-3-nitro-chloropyridine (II). 4-Fluorobenzylamine (III) reacts in dioxane and in the presence of triethylamine with (II), resulting in the 2-amino-3-nitro-6-p-fluorobenzylamine derivative (IV). The latter is hydrated and in situ the 3-amino group is condensed with ethyl chloroformate leading to the stable 2-amino-3-carbethoxyamino-6-(p-fluorobenzylamino)pyridine (Flupirtine).

参考文献No.700766
标题:
作者:Bebenburg, W.v.; Engel, J.; Sheldrick, W.S.; Thiele, K.
来源:Chem Ztg 1981,105(10),217
合成路线图解说明:

The reaction of 2,6-dichloro-3-nitropyridine (I) with ammonia yields 2-amino-3-nitro-chloropyridine (II). 4-Fluorobenzylamine (III) reacts in dioxane and in the presence of triethylamine with (II), resulting in the 2-amino-3-nitro-6-p-fluorobenzylamine derivative (IV). The latter is hydrated and in situ the 3-amino group is condensed with ethyl chloroformate leading to the stable 2-amino-3-carbethoxyamino-6-(p-fluorobenzylamino)pyridine (Flupirtine).

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