Pyrextramine-药物合成数据库

【药物名称】Pyrextramine

化学结构式(Chemical Structure):

参考文献No.	53619
标题:	Pyrextramine
作者:	Brasili, L.
来源:	Drugs Fut 1986,11(1),32

合成路线图解说明: N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.

参考文献No.	555887
标题:	Structure-activity relationships among benextramine-related tetraamine disulfides at peripheral alpha-adrenoreceptors
作者:	Angeli, P.; Brasili, L.; Brancia, E.; Giardina,.D.; Quaglia, W.; Melchiorre, C.
来源:	J Med Chem 1985,28(11),1643

合成路线图解说明: N1,N1'-Dithiobis(ethane-2,1-diyl)bis(hexane-1,6-diamine) (II) is prepared starting from 6-aminohexylcyste amine (I) by potassium ferricyanide oxidation. The condensation of (II) with pyrrol 2-carboxaldehyde and subsequent reduction with NaHB4 of the resulting Schitf base gives (III), which is crvstallized as tetraoxatate.