【药物名称】Talosalate, BA-760402
化学结构式(Chemical Structure):
参考文献No.3441
标题:Nouveaux esters de l'acide benzoique substitue
作者:(Laboratorios Bag?
来源:BE 0884978
合成路线图解说明:

1) The reaction of 3-bromophthalide with 2-hydroxybenzoic acid (I), previously salified with triethylamine in refluxing acetone gives 1,3-dihydro-3-oxo-1-isobenzofuranyl 2-hydroxybenzoate (II). Compound (II) is acetylated with acetic anhydride, using sulfuric acid as catalizer.

参考文献No.45891
标题:Methods of treating mammals suffering from inflammation and pain
作者:Los, M.A. (Laboratorios Bag?
来源:BE 0858864; JP 8162049; US 4256760
合成路线图解说明:

2) By condensation of an organic salt of 2-acetyloxybenzoic acid (III) with 3-bromophthalide.

参考文献No.53731
标题:Talosalate
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1986,11(5),394
合成路线图解说明:

1) The reaction of 3-bromophthalide with 2-hydroxybenzoic acid (I), previously salified with triethylamine in refluxing acetone gives 1,3-dihydro-3-oxo-1-isobenzofuranyl 2-hydroxybenzoate (II). Compound (II) is acetylated with acetic anhydride, using sulfuric acid as catalizer.

合成路线图解说明:

2) By condensation of an organic salt of 2-acetyloxybenzoic acid (III) with 3-bromophthalide.

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