Norfloxacin succinil, Eminor-药物合成数据库

【药物名称】Norfloxacin succinil, Eminor

化学结构式(Chemical Structure):

参考文献No.	2722
标题:	Cpds. having antibacterial activity, process for their preparation and pharmaceutical compsns. Containing them
作者:	Di Schiena, M. (Farmades)
来源:	EP 0155006

合成路线图解说明: By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.

参考文献No.	113259
标题:	NORFLOXACIN SUCCINIL
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1990,15(6),578

合成路线图解说明: By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane. Acetic acid can also be used as solvent in the acylation.