Indolidan, LY-195115-药物合成数据库

【药物名称】Indolidan, LY-195115

化学结构式(Chemical Structure):

参考文献No.	53867
标题:	LY-195115
作者:	Hayes, J.S.; Robertson, D.W.
来源:	Drugs Fut 1986,11(5),377

合成路线图解说明: Rearrangement of 2-methylpropanoic acid, 2-phenylhydrazide (I) provides 1,3-dihydro-3,3-dimethyl-2H-indol-2-one (II). Friedel Crafts' acylation of (II) with succinic anhydride in an aluminum chloride/DMF melt results in the formation of 4-oxobutanoic acid (III). Cyclization of (III) with hydrazine in refluxing ethanol completes the preparation of LY-195115.

参考文献No.	89175
标题:	Dihydropyridazinone cardiotonics: The discovery and inotropic activity of 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one
作者:	Robertson, D.W.; et al.
来源:	J Med Chem 1986,29(10),1832-40

合成路线图解说明: Rearrangement of 2-methylpropanoic acid, 2-phenylhydrazide (I) provides 1,3-dihydro-3,3-dimethyl-2H-indol-2-one (II). Friedel Crafts' acylation of (II) with succinic anhydride in an aluminum chloride/DMF melt results in the formation of 4-oxobutanoic acid (III). Cyclization of (III) with hydrazine in refluxing ethanol completes the preparation of LY-195115.