【药物名称】Tenilsetam, CAS-997
化学结构式(Chemical Structure):
参考文献No.9832
标题:Novel piperazinones, their preparation and use
作者:Beyerle, R.; Bender, H.; Schindler, U.; Nitz, R.-E.; Martorana, P.A. (Cassella AG)
来源:DE 3132882; US 4598079
合成路线图解说明:

The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III), which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.

参考文献No.39948
标题:Substd. 5,6-dihydro-2(1H)-pyrazinones
作者:Tilford, C.H.; Carr, A.A. Jr.; Kuhn, W.L. (Aventis Pharmaceuticals, Inc.)
来源:US 3056784
合成路线图解说明:

The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III), which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.

参考文献No.62372
标题:Telnisetam
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1988,13(2),130
合成路线图解说明:

The cyclization of ethyl 2-(2-thienyl)glyoxylate (I) with ethylenediamine (II) in refluxing ethanol gives 3-(2-thienyl)-1,2,5,6-tetrahydropyrazin-2-one (III), which is reduced with H2 over Raney Nickel (RaNi) in hot ethanol at 50 bar.

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