Pamicogrel, TO-192, KBT-3022, KB-3022, Paminate-药物合成数据库

【药物名称】Pamicogrel, TO-192, KBT-3022, KB-3022, Paminate

化学结构式(Chemical Structure):

参考文献No.	3327
标题:	Novel 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazoles, process for the preparation thereof and pharmaceutical compsn. containing the same
作者:	Yoshino, K.; Seko, N.; Yokota, K.; Ito, K.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.)
来源:	EP 0159677; JP 1985222481; JP 1986033186; JP 1986200985; US 4659726

合成路线图解说明: The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.

参考文献No.	130589
标题:	KBT-3022
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1991,16(2),105

合成路线图解说明: The cyclization of alpha-bromo-4,4'-dimethoxidesoxybenzoin (I) with pyrrole-2-carbothioamide (II) in hot acetonitrile gives 4,5-bis(4-methoxyphenyl)-2-(pyrrol-2-yl)thiazole (III), which is then condensed with ethyl bromoacetate (IV) by means of NaOH and tetrabutylammonium bromide in refluxing dichloromethane - water.