【药物名称】Nalmetrene(former INN, USAN), Nalmefene, NIH-10365(HCl), ORF-11676, JF-1, Cessal, Soberal, Alcofene, Revex(HCl), Arthene, Cervene, Incystene
化学结构式(Chemical Structure):
参考文献No.46479
标题:17-Substituted-6-desoxy-7,8-dihydro-6alpha-methylnoroxymorphone narcotic antagonists
作者:Hermann, E.C.; Lee, K.T.; Myers, M.J. (DuPont Pharmaceuticals Co.)
来源:EP 0039066; JP 167687; US 4322426
合成路线图解说明:

By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.

参考文献No.54368
标题:Nalmefene
作者:Serradell, M.N.; Casta馿r, J.
来源:Drugs Fut 1984,9(7),518
合成路线图解说明:

By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.

参考文献No.607978
标题:Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists
作者:Heilman, R.D.; Hahn, E.F.; Fishman, J.
来源:J Med Chem 1975,18(3),259-262
合成路线图解说明:

By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.

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