MCI-154-药物合成数据库

【药物名称】MCI-154

化学结构式(Chemical Structure):

参考文献No.	2511
标题:	6-(p-Heterocyclylaminophenyl)pyridazin-3-one derivs.
作者:	Kobayashi, M.; Narimatsu, A.; Furuya, R.; Shimooda, I.; Kitada, Y.; Okushima, H. (Mitsubishi Chemical Corp.)
来源:	EP 0145019; JP 1985126282; JP 1985197672; US 4661484; US 4971968

合成路线图解说明: By condensation of 6-(4aminophenyl)2,3,4,5-tetrahydropyridazin-3-one (I) with 4-bromopyridine (II) in hot DMF, followed by extraction of the free base with Na2CO3 and treatment with ethanolic HCl.

参考文献No.	59502
标题:	MCI-154
作者:	Casta馿r, R.M.; Serradell, M.N.; Casta馿r, J.
来源:	Drugs Fut 1987,12(9),856

合成路线图解说明: By condensation of 6-(4aminophenyl)2,3,4,5-tetrahydropyridazin-3-one (I) with 4-bromopyridine (II) in hot DMF, followed by extraction of the free base with Na2CO3 and treatment with ethanolic HCl.