Tamolarizine hydrochloride, NC-1100-药物合成数据库

【药物名称】Tamolarizine hydrochloride, NC-1100

化学结构式(Chemical Structure):

参考文献No.	4201
标题:	New piperazine derivs., their salts and pharmaceuticals for improving cerebral circulation
作者:	Mitsuo, M. (Nippon Chemiphar Co., Ltd.)
来源:	DE 3326148; ES 8603449

合成路线图解说明: The reaction of 1-(diphenylmethyl)piperazine (I) with 3,4-dimethoxyphenacyl bromide (II) by means of triethylamine in isopropanol gives alpha-[4-(diphenylmethyl)-1-piperazinyl]-3,4-dimethoxyacetophenone (III), which is then reduced with NaBH4 in ethanol-CHCl3.

参考文献No.	80596
标题:	NC-1100
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(4),334

合成路线图解说明: The reaction of 1-(diphenylmethyl)piperazine (I) with 3,4-dimethoxyphenacyl bromide (II) by means of triethylamine in isopropanol gives alpha-[4-(diphenylmethyl)-1-piperazinyl]-3,4-dimethoxyacetophenone (III), which is then reduced with NaBH4 in ethanol-CHCl3.