OPC-4392-药物合成数据库

【药物名称】OPC-4392

化学结构式(Chemical Structure):

参考文献No.	39949
标题:	Pharmaceutically useful carbostyril derivs.
作者:	Banno, K.; Fujioka, T.; Nakagawa, K.; Oshiro, Y. (Otsuka Pharmaceutical Co., Ltd.)
来源:	DE 2912105; FR 2421174; US 4734416

合成路线图解说明: The condensation of 7-hydroxycarbostyryl (I) with 1-bromo-3-chloropropane (II) by means of KOH in hot isopropranol gives 7-(3-chloropropoxy)carbostyryl (III), which is then allowed to react with 1-(2,3-dimethylpheny)piperazine (IV) by means of NaI and NaHCO3 in hot acetone.

参考文献No.	70085
标题:	OPC-4392
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(10),931

合成路线图解说明: The condensation of 7-hydroxycarbostyryl (I) with 1-bromo-3-chloropropane (II) by means of KOH in hot isopropranol gives 7-(3-chloropropoxy)carbostyryl (III), which is then allowed to react with 1-(2,3-dimethylpheny)piperazine (IV) by means of NaI and NaHCO3 in hot acetone.