Vintoperol, RT-3003, RGH-2981-药物合成数据库

【药物名称】Vintoperol, RT-3003, RGH-2981

化学结构式(Chemical Structure):

参考文献No.	55074
标题:	RGH-2981
作者:	N骻r醖i, M.
来源:	Drugs Fut 1986,11(10),853

合成路线图解说明: Conversion of racemic 1-ethyl-2,3,4,6,7,10-hexahydroindolo[2,3-a] quinolizine (I), an intermediate in the synthesis of vincamine, to the base and reaction of the latter with paraformaldehyde gives the 1-hydroxymethyl compound (II), which is acetylated to give the acetate (III). (III) is separated to its enantiomers by salt formation with (+)- (2R,3R)-tartaric acid, followed by fractional crystallization. Treatment of the separated tartrates with sodium methoxide gives the optically active bases, i.e., (+)-(II) and (-) (II) (RGH-2981).

参考文献No.	700318
标题:
作者:	Somogyi, A.; Rohner, H.-G.; Gugler, R.
来源:	J Org Chem 1985,50(1),3760

合成路线图解说明: Conversion of racemic 1-ethyl-2,3,4,6,7,10-hexahydroindolo[2,3-a] quinolizine (I), an intermediate in the synthesis of vincamine, to the base and reaction of the latter with paraformaldehyde gives the 1-hydroxymethyl compound (II), which is acetylated to give the acetate (III). (III) is separated to its enantiomers by salt formation with (+)- (2R,3R)-tartaric acid, followed by fractional crystallization. Treatment of the separated tartrates with sodium methoxide gives the optically active bases, i.e., (+)-(II) and (-) (II) (RGH-2981).