RS-04, RS-481, RS-0481-药物合成数据库

【药物名称】RS-04, RS-481, RS-0481

化学结构式(Chemical Structure):

参考文献No.	63023
标题:	RS-0481
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1988,13(7),627

合成路线图解说明: The benzoylation of thiazolidine-4(R)-carboxylic acid (I) with benzoyl chloride (II) by means of NaOH in acetone water gives the corresponding N-benzoyl derivative (III), which is then condensed with alpha-(R)-methylbenzylamine (IV) by means of isobutyl chloroformate and triethylamine in dichloromethane.

参考文献No.	900148
标题:	Amino acid derivatives having anti-tumor activity and compositions containing them.
作者:	Matsui, T.; Nagano, M.; KLitamura, K.; Shimizu, F. (Sankyo Co., Ltd.)
来源:	EP 0173441; ES 8703830; US 4904680

合成路线图解说明: The benzoylation of thiazolidine-4(R)-carboxylic acid (I) with benzoyl chloride (II) by means of NaOH in acetone water gives the corresponding N-benzoyl derivative (III), which is then condensed with alpha-(R)-methylbenzylamine (IV) by means of isobutyl chloroformate and triethylamine in dichloromethane.