Galamustine hydrochloride, G-6-M, C6-GalM, C6-GLM, C6-Galactose mustard-药物合成数据库

【药物名称】Galamustine hydrochloride, G-6-M, C6-GalM, C6-GLM, C6-Galactose mustard

化学结构式(Chemical Structure):

参考文献No.	105101
标题:	6-bis-(2-Chloroethyl)amino-6-deoxy-D-galactopyranose hydrochloride: Synthesis, chemical characterization, murine P388 antitumor activity, and bone marrow toxicity
作者:	Schein, P.S.; Green, D.; Hammer, C.F.; McPherson, E.; Talebian, A.
来源:	J Pharm Sci 1989,78(11),918-21

合成路线图解说明: G-6-M is prepared as shown. All secondary hydroxyl groups of D-galactopyranose were protected by vicinal capping into bis(acetonides) yielding 1,2:3,4-di-O-isopropylidene-D-galactopyranose. This was tosylated at 6-CH2OH and alkylated at C-6 with diethanolamine. The hydroxyethyl groups of compound (II) were chlorinated and the acetonides deblocked with dilute aqueous acid to give 6-bis(2-chloroethyl)amino-6-deoxy-D-galactopyranose hydrochloride in an overall conversion of ca. 42%.

参考文献No.	132960
标题:	Galamustine Hydrochloride
作者:	Plasee, T.F.
来源:	Drugs Fut 1991,16(3),205

合成路线图解说明: G-6-M is prepared as shown. All secondary hydroxyl groups of D-galactopyranose were protected by vicinal capping into bis(acetonides) yielding 1,2:3,4-di-O-isopropylidene-D-galactopyranose. This was tosylated at 6-CH2OH and alkylated at C-6 with diethanolamine. The hydroxyethyl groups of compound (II) were chlorinated and the acetonides deblocked with dilute aqueous acid to give 6-bis(2-chloroethyl)amino-6-deoxy-D-galactopyranose hydrochloride in an overall conversion of ca. 42%.