AZP-药物合成数据库

【药物名称】AZP

化学结构式(Chemical Structure):

参考文献No.	68073
标题:	AZP
作者:	Eastland, G.
来源:	Drugs Fut 1988,13(9),815

合成路线图解说明: To a stirred solution of trans N3P3Az2Cl4 (I) in 15 ml of benzene, cooled to 5 C, a solution of 50 mmol of MeNH2 in 20 ml of benzene is added dropwise. After warming to room temperature and allowing the reaction to proceed over a period of 18 h, the temperature of the reaction mixture is raised to 50 C for an additional 6 h. The precipitated amine hydrochloride salt is filtered off and washed with benzene. The washings are combined with the filtrate and evaporated by vacuum. The crude product is recrystallized from benzene

参考文献No.	547098
标题:	Isomer-dependent cytostatic activity of bis(1-azir
作者:	van der Huizen, A.A.; Wilting, T.; van de Grampel, J.C.; Lelieveld, P.; van der Meer-Kalverkamp, A.; Lamberts, H.B.; Mulder, N.H.
来源:	J Med Chem 1986,291341

合成路线图解说明: To a stirred solution of trans N3P3Az2Cl4 (I) in 15 ml of benzene, cooled to 5 C, a solution of 50 mmol of MeNH2 in 20 ml of benzene is added dropwise. After warming to room temperature and allowing the reaction to proceed over a period of 18 h, the temperature of the reaction mixture is raised to 50 C for an additional 6 h. The precipitated amine hydrochloride salt is filtered off and washed with benzene. The washings are combined with the filtrate and evaporated by vacuum. The crude product is recrystallized from benzene