Dotarizine, FI-6026-药物合成数据库

【药物名称】Dotarizine, FI-6026

化学结构式(Chemical Structure):

参考文献No.	49772
标题:	Piperazine derivs., a process for preparing them and pharmaceutical compsns.
作者:	Foguet, R.; Gubert, S.; Raga, M.M.; Ortiz, J.A.; Sacrist醤, A. (Ferrer Internacional SA)
来源:	EP 0097340

合成路线图解说明: The title compound was synthesized by alkylation of 1-benzhydrylpiperazine (I) with 2-(3-chloropropyl)-2-phenyl-1,3-dioxolan (II) in the presence of NaHCO3 in refluxing EtOH.