This compound can be prepared by two different ways: 1) The dehydrogenation of 17alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione (I) with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in refluxing dioxane gives 17alpha-acetoxy-6-chloropregna-1,4,6-triene-3,20-trione (II), which is oxidized with OsO4 and NaIO4 in refluxing dioxane, yielding 17alpha-acetoxy-6-chloro-1alpha-hydroxy-2-oxapregna-4,6-diene-3,20-dion e (III). Finally, this compound is treated with NaBH4 and NaHCO3 in methanol-THF. 2) Epoxidation of 17alpha-acetoxypregna-1,4,6-triene-3,20-dione (IV) with m-chloroperbenzoic acid (MCPBA) in chloroform gives 17alpha-acetoxy-6alpha,7alpha-epoxypregnan-1,4-diene-3,20-dione (V), which is treated with ozone in pyridine at -30 C, yielding 17alpha-acetoxy-6alpha,7alpha-epoxy-1alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VI). The reduction of (VI) with NaBH4 in methanol-THF followed by epoxide ring opening with concentrated HCl affords 17alpha-acetoxy-6beta-chloro-7alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VII), which is acetylated with acetic anhydride in pyridine to the diacetate (VIII). Finally, this compound is treated with potassium acetate in hot DMF to afford the title product.

This compound can be prepared by two different ways: 1) The dehydrogenation of 17alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione (I) with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in refluxing dioxane gives 17alpha-acetoxy-6-chloropregna-1,4,6-triene-3,20-trione (II), which is oxidized with OsO4 and NaIO4 in refluxing dioxane, yielding 17alpha-acetoxy-6-chloro-1alpha-hydroxy-2-oxapregna-4,6-diene-3,20-dion e (III). Finally, this compound is treated with NaBH4 and NaHCO3 in methanol-THF. 2) Epoxidation of 17alpha-acetoxypregna-1,4,6-triene-3,20-dione (IV) with m-chloroperbenzoic acid (MCPBA) in chloroform gives 17alpha-acetoxy-6alpha,7alpha-epoxypregnan-1,4-diene-3,20-dione (V), which is treated with ozone in pyridine at -30 C, yielding 17alpha-acetoxy-6alpha,7alpha-epoxy-1alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VI). The reduction of (VI) with NaBH4 in methanol-THF followed by epoxide ring opening with concentrated HCl affords 17alpha-acetoxy-6beta-chloro-7alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VII), which is acetylated with acetic anhydride in pyridine to the diacetate (VIII). Finally, this compound is treated with potassium acetate in hot DMF to afford the title product.

This compound can be prepared by two different ways: 1) The dehydrogenation of 17alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione (I) with 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) in refluxing dioxane gives 17alpha-acetoxy-6-chloropregna-1,4,6-triene-3,20-trione (II), which is oxidized with OsO4 and NaIO4 in refluxing dioxane, yielding 17alpha-acetoxy-6-chloro-1alpha-hydroxy-2-oxapregna-4,6-diene-3,20-dion e (III). Finally, this compound is treated with NaBH4 and NaHCO3 in methanol-THF. 2) Epoxidation of 17alpha-acetoxypregna-1,4,6-triene-3,20-dione (IV) with m-chloroperbenzoic acid (MCPBA) in chloroform gives 17alpha-acetoxy-6alpha,7alpha-epoxypregnan-1,4-diene-3,20-dione (V), which is treated with ozone in pyridine at -30 C, yielding 17alpha-acetoxy-6alpha,7alpha-epoxy-1alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VI). The reduction of (VI) with NaBH4 in methanol-THF followed by epoxide ring opening with concentrated HCl affords 17alpha-acetoxy-6beta-chloro-7alpha-hydroxy-2-oxapregn-4-ene-3,20-dione (VII), which is acetylated with acetic anhydride in pyridine to the diacetate (VIII). Finally, this compound is treated with potassium acetate in hot DMF to afford the title product.