TK-117-药物合成数据库

【药物名称】TK-117

化学结构式(Chemical Structure):

参考文献No.	5072
标题:	5-Fluoro-(beta-uridine or 2'-deoxy-beta-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same
作者:	Terashima, N.; Kitayama, I.; Yamaguchi, T.; Hiraiwa, T.; Omori, M.; Senoura, M.; Yotsuji, M.; Kodama, T.; Kodama, Y.; Aoyama, H. (Toyama Chemical Co., Ltd.)
来源:	DE 2923368

合成路线图解说明: The acylation of 3',5'-di-O-(chloroacetyl)-5-fluoro-2'-deoxyuridine (I) with 3,4-methylenedioxybenzoyl chloride (II) by means of triethylamine in dichloromethane gives 3',5'-di-O-(chloroacetyl)-3-(3,4-methylenedioxybenzoyl)-2'-deoxy-5-fluorouridine (III), which is then hydrolyzed with triethylamine in methanol-THF.

参考文献No.	77891
标题:	TK-117
作者:	Casta馿r, J.; Casta馿r, R.M.; Hoshi, A.; Serradell, M.N.
来源:	Drugs Fut 1987,12(9),865

合成路线图解说明: The acylation of 3',5'-di-O-(chloroacetyl)-5-fluoro-2'-deoxyuridine (I) with 3,4-methylenedioxybenzoyl chloride (II) by means of triethylamine in dichloromethane gives 3',5'-di-O-(chloroacetyl)-3-(3,4-methylenedioxybenzoyl)-2'-deoxy-5-fluorouridine (III), which is then hydrolyzed with triethylamine in methanol-THF.