【药物名称】Didox, NSC-324360
化学结构式(Chemical Structure):
参考文献No.5073
标题:Hydroxy benzohydroxamic acids and benzamides
作者:Van't Riet, B.; Elford, H.L.; Wampler, G.L. (Molecules for Health, Inc.)
来源:US 4263322
合成路线图解说明:

The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II), which is then treated with hydroxylamine in water containing NaOH.

参考文献No.99541
标题:Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: Inhibition of ribonucleotide reductase and antitumor activity
作者:Van't Riet, B.; Wampler, G.L.; Elford, H.W.
来源:J Med Chem 1979,22(5),589-92
合成路线图解说明:

The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II), which is then treated with hydroxylamine in water containing NaOH.

参考文献No.99722
标题:DIDOX
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1990,15(1),22
合成路线图解说明:

The esterification of 3,4-dihydroxybenzoic acid (I) with refluxing methanol - H2SO4 gives the corresponding methyl ester (II), which is then treated with hydroxylamine in water containing NaOH.

Drug Information Express,Drug R&D,Chemical Database,Patent Search.
Copyright © 2006-2024 Drug Future. All rights reserved.Contact Us