Mofezolac, N-22, Disopain-药物合成数据库

【药物名称】Mofezolac, N-22, Disopain

化学结构式(Chemical Structure):

参考文献No.	8190
标题:	3,4-Diaryl-5-acetic acid cpds., process for prepar
作者:	Micetich, R.G.; Shaw, C.-C.; Rastogi, R.B. (CDC Life Sciences Inc.)
来源:	EP 0026928; US 4327222

合成路线图解说明: The reaction of desoxyanisoin (I) with hydroxylamine in methanol gives the corresponding oxime (I), which is cyclized with ethyl acetate (III) by means of n-butyllithium in THF yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole (IV). Finally, this compound is condensed with CO2 by means of n-butyllithium in THF.

参考文献No.	77459
标题:	N-22
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(12),1050

合成路线图解说明: The reaction of desoxyanisoin (I) with hydroxylamine in methanol gives the corresponding oxime (I), which is cyclized with ethyl acetate (III) by means of n-butyllithium in THF yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole (IV). Finally, this compound is condensed with CO2 by means of n-butyllithium in THF.