Nemorubicin, PNU-152243, FCE-23762-药物合成数据库

【药物名称】Nemorubicin, PNU-152243, FCE-23762

化学结构式(Chemical Structure):

参考文献No.	5151
标题:	Novel morpholino derivs. of daunorubicins and doxorubicins
作者:	Bargiotti, A.; Zini, P.; Penco, S.; Giuliani, F. (Pharmacia Corp.)
来源:	BE 0904431; DE 3609052; GB 2172594; JP 1986221194; US 4672057

合成路线图解说明: By condensation of 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester (I) with N-methylaniline (II) by heating at 125 C and distillation of the ethanol formed.

合成路线图解说明: The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II), which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.

参考文献No.	433151
标题:	Nemorubicin
作者:	Graul, A.; Leeson, P.; Casta馿r, J.
来源:	Drugs Fut 1997,22(12),1239

合成路线图解说明: The oxidative cleavage of methyl beta-L-arabinopyranoside (I) with sodium periodate in water gives the dialdehyde (II), which is then cyclized with daunorubicin by means of NaHCO3 and sodium cyanoborohydride in acetonitrile/water.