Loxoprofen sodium, CS-600G, LX-A, CS-600, Loxonin-药物合成数据库

【药物名称】Loxoprofen sodium, CS-600G, LX-A, CS-600, Loxonin

化学结构式(Chemical Structure):

参考文献No.	46039
标题:	Substituted phenylacetic acid derivatives and process for the preparation thereof
作者:	Misaka, E.; Terada, A.; Wachi, K. (Sankyo Co., Ltd.)
来源:	DE 2814556; ES 468578; FR 2395256; GB 1580113; US 4161538

合成路线图解说明: The reaction of ethyl 2-oxocyclopentanecarboxylate (I) with ethyl 2-(4-chloromethylphenyl)propionate (II) by means of KOH in hot DMF gives ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclopentan-1-ylmethyl)phenyl]propionate (III), which is then hydrolyzed and decarboxylated by treatment with 47% HBr in refluxing dioxane.

参考文献No.	56163
标题:	Loxoprofen
作者:	Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1984,9(1),22

合成路线图解说明: The reaction of ethyl 2-oxocyclopentanecarboxylate (I) with ethyl 2-(4-chloromethylphenyl)propionate (II) by means of KOH in hot DMF gives ethyl 2-[4-(1-ethoxycarbonyl-2-oxocyclopentan-1-ylmethyl)phenyl]propionate (III), which is then hydrolyzed and decarboxylated by treatment with 47% HBr in refluxing dioxane.