【药物名称】Troxipide, KU-54, Aplace
化学结构式(Chemical Structure):
参考文献No.56188
标题:KU-54
作者:Blancafort, P.; Casta馿r, J.; Dharma, A.P.; Serradell, M.N.
来源:Drugs Fut 1979,4(12),882
合成路线图解说明:

The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III), which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.

参考文献No.607656
标题:New antiulcer agents. 1. Syntheses and biological activities of 1-acyl-2-, -3- and -4-substituted benzamidopiperidines
作者:Irikura, T.; Kasuga, K.
来源:J Med Chem 1971,14(4),357-361
合成路线图解说明:

The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III), which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.

参考文献No.701001
标题:Benzoylamino substituted 1-benzoylpiperidines
作者:Irikura, T.; et al.
来源:US 3647805
合成路线图解说明:

The condensation of 3,4,5-trimethoxybenzoyl chloride (I) with 3-aminopyridine (II) by means of pyridine in benzene gives 3-(3,4,5-trimethoxybenzamido)pyridine (III), which is hydrogenated with H2 over Pd/C in ethanol-water-HCl.

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