【药物名称】Crisnatol mesilate, 770U82 mesylate, BW-A770U mesylate
化学结构式(Chemical Structure):
参考文献No.5321
标题:Polycyclic aromatic cpds
作者:Bair, K.W. (Glaxo Wellcome plc)
来源:EP 0125702; US 4719047
合成路线图解说明:

The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II), which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene, followed by dilution with ethanol and reduction with sodium cyanoborohydride.

参考文献No.5322
标题:Polycyclic biocidal cpds., their synthesis, formulations containing them
作者:Bair, K.W. (Glaxo Wellcome plc)
来源:EP 0182609; ES 8706102; ES 8802415; ES 8802481
合成路线图解说明:

The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II), which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene, followed by dilution with ethanol and reduction with sodium cyanoborohydride.

参考文献No.160501
标题:2-[(Arylmethyl)amino]-2-methyl-1,3-propanediol DNA intercalators. An examination of the effects of aromatic ring variation on antitumor activity and DNA binding
作者:Bair, K.W.; Andrews, C.W.; Tuttle, R.L.; Knick, V.C.; Cory, M.; McKee, D.D.
来源:J Med Chem 1991,34(7),1983-90
合成路线图解说明:

The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II), which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene, followed by dilution with ethanol and reduction with sodium cyanoborohydride.

参考文献No.199870
标题:Crisnatol Mesylate
作者:Casta馿r, J.; Prous, J.
来源:Drugs Fut 1993,18(3),216
合成路线图解说明:

The formylation of chrysene (I) with dichloromethyl methyl ether by means of SnCl4 in o-dichlorobenzene gives chrysene-6-carboxaldehyde (II), which is then reductocondensed with 2-amino-2-methylpropane-1,3-diol (III) by means of p-toluenesulfonic acid in refluxing toluene, followed by dilution with ethanol and reduction with sodium cyanoborohydride.

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