【药物名称】Clenbuterol hydrochloride, NAB-365, Siropent
化学结构式(Chemical Structure):
参考文献No.56432
标题:Clenbuterol
作者:Casta馿r, J.; Thorpe, P.
来源:Drugs Fut 1976,1(5),221
合成路线图解说明:

By bromination of 4-amino-3,5-dichloroacetophenone (I) with Br2 in CHCl3 to give 4-amino-3,5-dichloro-alpha-bromoacetophenone (II), m.p. 140-5 C, which is condensed with tert-butylamine (III) in CHCl3 to 4-amino-3,5-dichloro-alpha-tertbutylaminoacetophenone hydrochloride (IV), m.p. 252-7 C; this product is finally reduced with NaBH4 in methanol.

参考文献No.604471
标题:Synthesen von neuen Amino-Halogen-substituierten Phenyl-amino鋞hanolen
作者:Keck, J.; et al.
来源:Arzneim-Forsch Drug Res 1972,22(5),861-869
合成路线图解说明:

By bromination of 4-amino-3,5-dichloroacetophenone (I) with Br2 in CHCl3 to give 4-amino-3,5-dichloro-alpha-bromoacetophenone (II), m.p. 140-5 C, which is condensed with tert-butylamine (III) in CHCl3 to 4-amino-3,5-dichloro-alpha-tertbutylaminoacetophenone hydrochloride (IV), m.p. 252-7 C; this product is finally reduced with NaBH4 in methanol.

参考文献No.701122
标题:Neue Verbindung 1-(4-Amino-3,5-dichlorphenyl)-2-tert-butylamino-鋞hanol
作者:Keck, J.; et al.
来源:DE 1793416
合成路线图解说明:

By bromination of 4-amino-3,5-dichloroacetophenone (I) with Br2 in CHCl3 to give 4-amino-3,5-dichloro-alpha-bromoacetophenone (II), m.p. 140-5 C, which is condensed with tert-butylamine (III) in CHCl3 to 4-amino-3,5-dichloro-alpha-tertbutylaminoacetophenone hydrochloride (IV), m.p. 252-7 C; this product is finally reduced with NaBH4 in methanol.

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