Reaction of 3-amino-5-acetyl-10,11-dihydro-5H-dibenz[b,f]azepine (I) with potassium hydroxide in n-propanol yields 3-amino-10,11-dihydro-5H-dibenz[b,f]azepine (II), which reacts with ethyl chloroformate to give 3-carbethoxyamino-10,11-dihydro-5H-dibenz[b,f]azepine (III). Reaction of (III) with chloroacetylchloride yields 3-carbethoxyamino-5-chloroacetyl-10,11-dihydro-5H-dibenz[b,f]azepine (IV), which is then reacted with dimethylamine to give 3-carbethoxyamino-5-dimethylaminoacetyl-10,11-dihydro-5H-dibenz[b,f] azepine (tiracizine) (V), with m.p. 135-7 C. Tiracizine hydrochloride is obtained by reaction of the base with hydrochloric acid in isopropanol.