【药物名称】D-16120
化学结构式(Chemical Structure):
参考文献No.323
标题:1-Cycloalkyl-3-acylpiperazine derivs.
作者:Engel, J.; Jakovlev, V.; Oepen, G.; Thiemer, K. (Degussa-H黮s AG)
来源:EP 0120465; US 4547505
合成路线图解说明:

The synthesis of D-16120 can be achieved by several methods: 1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120. 2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.

参考文献No.56536
标题:D-16120
作者:Oepen, G.; Nickel, B.; Molliere, M.; Engel, J.
来源:Drugs Fut 1987,12(3),209
合成路线图解说明:

The synthesis of D-16120 can be achieved by several methods: 1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120. 2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.

参考文献No.293759
标题:Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl)piperazine (D-16120) by rat liver microsomes
作者:Caputo, O.; Rocco, F.; Grosa, G.
来源:Eur J Drug Metab Pharmacokinet 1994,19(4),303
合成路线图解说明:

The synthesis of D-16120 can be achieved by several methods: 1) Aminolysis of 3-cyclohexylpropionyl chloride (I) with 2-ethoxyphenylpiperazine (II) in the presence of triethylamine yields D-16120. 2) Reaction of ethyl 3-cyclohexylpropionate (III) with 2-ethoxyphenylpiperazine (IV) also gives D-16120.

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