【药物名称】Edaravone, MCI-186, Radicut
化学结构式(Chemical Structure):
参考文献No.5670
标题:Prophylactic and therapeutic agent for circulatory disorders
作者:Nishi, H.; Watanabe, T.; Yuki, S.; Morinaka, Y.; Iseki, K.; Sakurai, H. (Mitsubishi Chemical Corp.)
来源:EP 0208874; JP 1987108814; US 4857542
合成路线图解说明:

By direct cyclization of phenylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol.

参考文献No.376470
标题:Edaravone
作者:Graul, A.; Casta馿r, J.
来源:Drugs Fut 1996,21(10),1014
合成路线图解说明:

By direct cyclization of phenylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol.

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