Flurofamide, EU-4534-药物合成数据库

【药物名称】Flurofamide, EU-4534

化学结构式(Chemical Structure):

参考文献No.	47476
标题:	N-[Diaminophosphinyl]arylcarboxamides
作者:	Bayless, A.V.; Millner, O.E. Jr. (Norwich Eaton)
来源:	US 4182881

合成路线图解说明: The reaction of p-fluorobenzamide (I) with phosphorus pentachloride (II) in refluxing CCl4, followed by a treatment with formic acid gives N-(dichlorophosphinyl)-p-fluorobenzamide (III), which is then treated with NH3 in CHCl3.

参考文献No.	575935
标题:	Flurofamide
作者:	Blancafort, P.; Casta馿r, J.; Serradell, M.N.
来源:	Drugs Fut 1982,7(10),734

合成路线图解说明: The reaction of p-fluorobenzamide (I) with phosphorus pentachloride (II) in refluxing CCl4, followed by a treatment with formic acid gives N-(dichlorophosphinyl)-p-fluorobenzamide (III), which is then treated with NH3 in CHCl3.