【药物名称】CPI-[(99m)-Tc], Tc-CPI, (99m)-Tc-CPI
化学结构式(Chemical Structure):
参考文献No.5897
标题:Carboxy, carboalkoxy and carbamile substd. isonitrile radionuclide complexes
作者:Jones, A.G.; Davison, A.; Kronauge, J.; Abrams, M.J. (Harvard College; Massachusetts Institute of Technology)
来源:EP 0213945
合成路线图解说明:

The esterification of 2-aminoisobutyric acid (I) with methanol - HCl gives the corresponding methyl ester (II), which is formylated with formic acid - acetic anhydride or methyl formate yielding the formamide (III). Dehydration of (III) with diphosgene (DPG) or POCl3 in pyridine affords methyl 2-isocyanoisobutyrate (CPI) (IV). Finally, this compound or its ZnBr2 complex [Zn(CPI)2Br2] is treated with 99mTcO4 and sodium dithionite or SnCl2 respectively, in ethanol-water solution. The radiochemical purity was >95%.

参考文献No.63549
标题:Myocardial imaging with Tc-99m CPI: Initial experience in human
作者:Holman, B.L.; Sporn, V.; Jones, A.G.; et al.
来源:J Nucl Med 1987,2813-18
合成路线图解说明:

The esterification of 2-aminoisobutyric acid (I) with methanol - HCl gives the corresponding methyl ester (II), which is formylated with formic acid - acetic anhydride or methyl formate yielding the formamide (III). Dehydration of (III) with diphosgene (DPG) or POCl3 in pyridine affords methyl 2-isocyanoisobutyrate (CPI) (IV). Finally, this compound or its ZnBr2 complex [Zn(CPI)2Br2] is treated with 99mTcO4 and sodium dithionite or SnCl2 respectively, in ethanol-water solution. The radiochemical purity was >95%.

参考文献No.143940
标题:[99m]-Tc-CPI
作者:Liu, X.-J.; Wang, X.-B.; Lahiri, A.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1990,15(9),883
合成路线图解说明:

The esterification of 2-aminoisobutyric acid (I) with methanol - HCl gives the corresponding methyl ester (II), which is formylated with formic acid - acetic anhydride or methyl formate yielding the formamide (III). Dehydration of (III) with diphosgene (DPG) or POCl3 in pyridine affords methyl 2-isocyanoisobutyrate (CPI) (IV). Finally, this compound or its ZnBr2 complex [Zn(CPI)2Br2] is treated with 99mTcO4 and sodium dithionite or SnCl2 respectively, in ethanol-water solution. The radiochemical purity was >95%.

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