【药物名称】Lomerizine hydrochloride, DE-090, KB-2796, Terranas, Migsis
化学结构式(Chemical Structure):
参考文献No.3330
标题:1-(2,3,4-Tri-methoxybenzyl)-4[bis(4-fluorophenyl)m
作者:Ito, K.; Kanazawa, T.; Ohtaka, H.; Tsukamoto, G. (Kanebo Pharmaceuticals, Ltd.)
来源:EP 0159566; ES 8702393; ES 8801236; ES 8801237; JP 1985222472; US 4663325
合成路线图解说明:

By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.

参考文献No.62398
标题:KB-2796
作者:Prous, J.; Casta馿r, J.
来源:Drugs Fut 1988,13(4),312
合成路线图解说明:

By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.

参考文献No.547105
标题:Benzylpiperazine derivatives. IV. Synthesis and ce
作者:Kanazawa, T.; Ohtaka, H.; Ito, K.; Stukamoto, G.
来源:Chem Pharm Bull 1987,35(8),3270
合成路线图解说明:

By reductocondensation of 2,3,4-trimethoxybenzaldehyde (I) with l-[bis(4-fluorophenyl)methyl] piperazine (II) by means of formic acid at 100-120 C.

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