Gevotroline hydrochloride, Wy-47384-药物合成数据库

【药物名称】Gevotroline hydrochloride, Wy-47384

化学结构式(Chemical Structure):

参考文献No.	63542
标题:	WY-47384
作者:	Andree, T.; Abou-Gharbia, M.
来源:	Drugs Fut 1988,13(6),541

合成路线图解说明: The reaction of 4-fluorophenylhydrazine hydrochloride (I) with N-carbethoxy-4-piperidone (II) under Fisher's conditions affords N2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyridol[4,3-b]indole (III). Treatment of (III) with Claisen's alkali affords the N-2 unsubstituted 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (IV), which is finally condensed with 3-pyridinylpropyl bromide hydrobromide (V) in DMF in the presence of triethyl amine (TEA). Compound (V) is obtained by refluxing 3-pyridinylpropanol with 48% hydrobromic acid.

参考文献No.	547106
标题:	Antipsychotic activity of substituted gamma-carbol
作者:	Abou-Gharbia, M.; Patel, U.R.; Webb, M.B.; Moyer, J.A.; Andree, T.H.; Muth, E.A.
来源:	J Med Chem 1987,301818

合成路线图解说明: The reaction of 4-fluorophenylhydrazine hydrochloride (I) with N-carbethoxy-4-piperidone (II) under Fisher's conditions affords N2-carbethoxy-8-fluoro-2,3,4,5-tetrahydro-1H-pyridol[4,3-b]indole (III). Treatment of (III) with Claisen's alkali affords the N-2 unsubstituted 8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (IV), which is finally condensed with 3-pyridinylpropyl bromide hydrobromide (V) in DMF in the presence of triethyl amine (TEA). Compound (V) is obtained by refluxing 3-pyridinylpropanol with 48% hydrobromic acid.