Wy-47288-药物合成数据库

【药物名称】Wy-47288

化学结构式(Chemical Structure):

参考文献No.	803830
标题:	Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor - A general route to novel antiinflammatory and antiallergy drugs
作者:	Kreft, A.F.; Failli, A.; Musser, J.H.; et al.
来源:	Drugs Exp Clin Res 1991,17381-387

合成路线图解说明: By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明: By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明: By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

参考文献No.	803831
标题:	Structure -activity relationships in the quinoline- containing class of inhibitors of 5-lipoxygenase (5-LO) enzyme translocation and activation
作者:	Marshall, L.A.; Wong, A.; Kreft, A.F.
来源:	Drugs Fut 1994,19(3),255

合成路线图解说明: By condensation of 1-naphthol (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明: By condensation of 2(S)-(6-hydroxy-2-naphthyl)propionic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.

合成路线图解说明: By condensation of 2-(2-fluoro-4'-hydroxybiphenyl-4-yl)acetic acid (I) with 2-(chloromethyl)quinoline (II) by means of NaH in DMF.