NDDP [cis-bis(neodecanoato)[trans-(R,R)-1,2-diaminocyclohexane]platinum (II)] is a platinum complex with the empirical formula C26H52N2O4Pt. However, the neodecanoic acid used in the synthesis is an isomeric mixture of at least 18 isomers. In order to evaluate their biological properties, the synthesis of various single isomers of NDDP has been performed. These compounds are: (I) Bis(2,2-dimethyloctanoato)(R,R-1,2-diaminocyclohexane)platinum (II); (II) Bis(2,2-dimethyloctanoato)(S,S-1,2-diaminocyclohexane)platinum (II); (III) Bis(4-ethyl-2,2-dimethylhexanoate)(R,R-1,2-diaminocyclohexane)platinum (II); (IV) Bis(4-ethyl-2,2-dimethylhexanoato)(S,S-1,2-diaminocyclohexane)platinum (II); (V) Bis(2-ethyl-2-methylheptanoato(R,R-1,2-diaminocyclohexane)platinum (II); (VI) Bis(2-ethyl-2-methylheptanoato)(S,S-1,2-diaminocyclohexane)platinum (II); (VII) Bis(2,2-diethylhexanoato)(R,R-1,2-diaminocyclohexane)platinum (II); (VIII) Bis(2,2-diethylhexanoato)(S,S-1,2-diaminocyclohexane)platinum (II); (IX) Bis(2,2-diethyl-4-methylpentanoato)(R,R-1,2-diaminocyclohexane)platinum (II); (X) Bis(2,2-diethyl-4-methylpentanoato)(S,S-1,2-diaminocyclohexane)platinum (II). The synthetic method was the reaction of (1,2-diaminocyclohexane)(sulfato)platinum (II) (XI) with the corresponding sodium salt of the neodecanoic acid (XII). The liposomal preparation was performed as follows: Solutions of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in CHCl3 with a molar ratio 7:3 were mixed with NDDP analogues in a weight ratio 15:1, and then the CHCl3 was evaporated in a rotary evaporator. Multilamellar liposomes were formed by adding 1 ml of 0.9% NaCl for each mg of Pt complex, and shaking for a few minutes.