Deferiprone, CP20, CGP-37391, CP020, L1, Ferriprox, Deferum, Kelfer-药物合成数据库

【药物名称】Deferiprone, CP20, CGP-37391, CP020, L1, Ferriprox, Deferum, Kelfer

化学结构式(Chemical Structure):

参考文献No.	226652
标题:	Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: Orally active iron chelators with clinical potential
作者:	Dobbin, P.S.; Hider, R.C.; Hall, A.D.; Taylor, P.D.; Sarpong, P.; Porter, J.B.; Xiao, G.; Van der Helm, D.
来源:	J Med Chem 1993,36(17),2448

合成路线图解说明: A new synthesis of L1 has been reported: The reaction of 3-benzyloxy-2-methyl-4H-pyran-4-one (I) with methylamine and NaOH in refluxing ethanol gives 3-benzyloxy-1,2-dimethylpyridin-4(1H)-one (II), which is deprotected by hydrogenolysis with H2 over Pd/C in ethanol.