Fotemustine, S-10036, Servier-10036, Muphoran-药物合成数据库

【药物名称】Fotemustine, S-10036, Servier-10036, Muphoran

化学结构式(Chemical Structure):

参考文献No.	8638
标题:	New nitrosourea derivs., process for preparing them and pharmaceutical compsns. containing them
作者:	Lavielle, G.; Cudennec, C. (ADIR et Cie.)
来源:	FR 2536075

合成路线图解说明: The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III), which is then treated with sodium nitrite and formic acid.

参考文献No.	109641
标题:	FOTEMUSTINE < Rec INN >
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(11),1042

合成路线图解说明: The condensation of 2-chloroethyl isocyanate (I) with diethyl 1-aminoethylphosphonate (II) in chloroform gives diethyl 1-[3-(2-chloroethyl)ureido]ethylphosphonate (III), which is then treated with sodium nitrite and formic acid.