Cericlamine hydrochloride, JO-1017-药物合成数据库

【药物名称】Cericlamine hydrochloride, JO-1017

化学结构式(Chemical Structure):

参考文献No.	6788
标题:	Aminoalcohols, process for their preparation and their applications, notable in therapy
作者:	Aubard, G.; Bure, J.; Calvet, A.P.; Gouret, C.; Grouhel, A.G.; Junien, J.-L. (Institut de Recherche Jouveinal)
来源:	EP 0237366; FR 2593499; JP 1987190150

合成路线图解说明: The reduction of (?-2-(3,4-dichlorobenzyl)alanine (I) with borane - dimethyl sulfide complex in refluxing THF gives (?-2-amino-3-(3,4-dichlorophenyl)-2-methylpropanol) (II), which is then methylated with formaldehyde in refluxing formic acid.

参考文献No.	138122
标题:	Cericlamine Hydrochloride
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1991,16(4),301

合成路线图解说明: The reduction of (?-2-(3,4-dichlorobenzyl)alanine (I) with borane - dimethyl sulfide complex in refluxing THF gives (?-2-amino-3-(3,4-dichlorophenyl)-2-methylpropanol) (II), which is then methylated with formaldehyde in refluxing formic acid.