Tazifylline hydrochloride, RS-49014-药物合成数据库

【药物名称】Tazifylline hydrochloride, RS-49014

化学结构式(Chemical Structure):

参考文献No.	139
标题:	Piperazine derivatives of theophylline
作者:	Favier, C.; Pinhas, H.; Beranger, S.; Pascal, J.-C. (Roche Bioscience)
来源:	EP 0033674; GB 2069487; JP 56120683; US 4374835

合成路线图解说明: The reaction of 1-bromo-3-chloropropane (I) with thiophenol (II) by means of NaOH in refluxing water gives 1-(phenylthio)-3-chloropropane (III), which is condensed with piperazine (IV) by means of NaOH in refluxing ethanol-water yielding 1-(3-phenylthiopropyl)piperazine (V). Finally, this compound is condensed with 7-(2,3-epoxypropyl)theophylline (VI) in refluxing ethanol.

参考文献No.	79480
标题:	Tazifylline Hydrochloride
作者:	Casta馿r, R.M.; Casta馿r, J.; Serradell, M.N.; Tester-Dalderup, C.
来源:	Drugs Fut 1987,12(11),1036

合成路线图解说明: The reaction of 1-bromo-3-chloropropane (I) with thiophenol (II) by means of NaOH in refluxing water gives 1-(phenylthio)-3-chloropropane (III), which is condensed with piperazine (IV) by means of NaOH in refluxing ethanol-water yielding 1-(3-phenylthiopropyl)piperazine (V). Finally, this compound is condensed with 7-(2,3-epoxypropyl)theophylline (VI) in refluxing ethanol.