Eltoprazine Hydrochloride, DU-28853-药物合成数据库

【药物名称】Eltoprazine Hydrochloride, DU-28853

化学结构式(Chemical Structure):

参考文献No.	62389
标题:	ELTOPRAZINE HYDROCHLORIDE < Prop INN >
作者:	Hartog, J.; Olivier, B.
来源:	Drugs Fut 1988,13(3),222

合成路线图解说明: Eltoprazine can be obtained in a 3-step procedure starting from 5-nitrobenzodioxane (I): Catalytic hydrogenation of benzodioxane (I) results in the aniline hydrochloride (II) in high yieId. From the crude product obtained after treatment of (II) with bischloroethylamine dihydrochloride and subsequent crystallization from ethanol, pure eltoprazine hydrochloride is isolated.

参考文献No.	900147
标题:	Method of preparing 5-amino-1,4-benzodioxane.
作者:	Martikus, R.S.; Udrenajte, E.B.; Daukshas, V.K.; Rimkunajte, L.V. (Viln G Univ Im V Kapuskasa)
来源:	SU 456521

合成路线图解说明: Eltoprazine can be obtained in a 3-step procedure starting from 5-nitrobenzodioxane (I): Catalytic hydrogenation of benzodioxane (I) results in the aniline hydrochloride (II) in high yieId. From the crude product obtained after treatment of (II) with bischloroethylamine dihydrochloride and subsequent crystallization from ethanol, pure eltoprazine hydrochloride is isolated.