Drohynol, IS-35-药物合成数据库

【药物名称】Drohynol, IS-35

化学结构式(Chemical Structure):

参考文献No.	63028
标题:	Drohynol
作者:	Markov, M.
来源:	Drugs Fut 1988,13(8),722

合成路线图解说明: Title compound is obtained by Mannich reaction after treatment of S-(-)-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1.2,3,4-tetrahydroisoquinoline hydrochloride (I) with paraformaldehyde using ethanol and catalytic amounts of hydrochloric acid.

参考文献No.	803918
标题:	Hexahydrodibenzo[a,f]quinolizine and method for their synthesis
作者:	Ivanov, Ch.; Vankov, S.; Nikolova, M.; Zhelyazkov, D.; Ivanova, N.; Markov, M.; Tanev, G.; Florin, A.; Ilieva, A.
来源:	License 32353, INRA S. 1982,

合成路线图解说明: Title compound is obtained by Mannich reaction after treatment of S-(-)-1-(3,4,5-trimethoxybenzyl)-6,7-dihydroxy-1.2,3,4-tetrahydroisoquinoline hydrochloride (I) with paraformaldehyde using ethanol and catalytic amounts of hydrochloric acid.