FO-152-药物合成数据库

【药物名称】FO-152

化学结构式(Chemical Structure):

参考文献No.	8366
标题:	Nucleoside derivs., their preparation and their us
作者:	Endo, T.; Sakai, K.; Chou, K.; Inamoto, Y.; Teshigawara, H. (Fuji Yakuhin Kogyo Co., Ltd.)
来源:	FR 2470774; US 4340728

合成路线图解说明: The acylation of 2',3'-O-isopropylidene-5-fluoro-uridine (II) with N-benzyloxycarbonylvaline (I) by means of 2,4,6-triisopropylbenzenesulfonyl chloride (TPS) in pyridine gives 5'-O(N-benzyloxycarbonylvalyl)-2',3'-O-isopropylidene-5-fluorouridine (III), which is treated with trifluoroacetic acid yielding 5'-O-(N-benzyloxycarbonylvalyl)-5-fluorouridine (IV). Finally, this compound is debenzylated by hydrogenation with H2 over Pd/C in isopropanol.

参考文献No.	63002
标题:	FO-152
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(6),516

合成路线图解说明: The acylation of 2',3'-O-isopropylidene-5-fluoro-uridine (II) with N-benzyloxycarbonylvaline (I) by means of 2,4,6-triisopropylbenzenesulfonyl chloride (TPS) in pyridine gives 5'-O(N-benzyloxycarbonylvalyl)-2',3'-O-isopropylidene-5-fluorouridine (III), which is treated with trifluoroacetic acid yielding 5'-O-(N-benzyloxycarbonylvalyl)-5-fluorouridine (IV). Finally, this compound is debenzylated by hydrogenation with H2 over Pd/C in isopropanol.