E-90/007, KW-2149, KT-6149-药物合成数据库

【药物名称】E-90/007, KW-2149, KT-6149

化学结构式(Chemical Structure):

参考文献No.	8051
标题:	Mitomycin derivs.
作者:	Kono, M.; Saito, Y.; Kanda, Y.; Kasai, M.; Sato, A.; Morimoto, M.; Ashizawa, T. (Kyowa Hakko Kogyo Co., Ltd.)
来源:	EP 0280741; JP 1988505196; US 5103018; WO 8801622

合成路线图解说明: The condensation of mitomycin A (I) with 2-(2-pyridyldithio)ethylamine (II) by means of triethylamine in methanol gives 7-N-[2-(2-pyridyldithio)ethyl]mitomycin C (III), which is then allowed to react with gamma-L-glutamylcysteamine (IV) in methanol. The gamma-L-glutamylcysteamine (IV) is obtained by deprotection of N,N'-bis[N-benzyloxycarbonyl-gamma-(alpha-benzyl)-L-glutamyl]cystamine (V) with anisole and trifluoroacetic acid giving the deprotected cystamine (VI), which is then reduced to the cysteamine (IV) with ethyl mercaptane.

参考文献No.	79252
标题:	KT-6149
作者:	Hoshi, A.; Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1989,14(2),127

合成路线图解说明: The condensation of mitomycin A (I) with 2-(2-pyridyldithio)ethylamine (II) by means of triethylamine in methanol gives 7-N-[2-(2-pyridyldithio)ethyl]mitomycin C (III), which is then allowed to react with gamma-L-glutamylcysteamine (IV) in methanol. The gamma-L-glutamylcysteamine (IV) is obtained by deprotection of N,N'-bis[N-benzyloxycarbonyl-gamma-(alpha-benzyl)-L-glutamyl]cystamine (V) with anisole and trifluoroacetic acid giving the deprotected cystamine (VI), which is then reduced to the cysteamine (IV) with ethyl mercaptane.