Nicorandil, RP-46417, SG-75, Adancor, Ikorel, Dancor, Sigmart-药物合成数据库

【药物名称】Nicorandil, RP-46417, SG-75, Adancor, Ikorel, Dancor, Sigmart

化学结构式(Chemical Structure):

参考文献No.	65911
标题:	SG-75
作者:	Thorpe, P.J.; Casta馿r, J.
来源:	Drugs Fut 1979,4(2),134

合成路线图解说明: The esteritication of nicotinic acid (I) with methanol and HCl or H2SO4 yields the corresponding methyl ester (II), which is treated with ethanolamine (A) to afford N-(beta-hydroxyethyl)nicotinamide (III). Finally, this compound is transformed into the nitrate ester by the usual methods.

参考文献No.	800241
标题:	Solubilizing agents. V. Pyridinecarboxamides
作者:	Masayoshi, S.
来源:	Yakugaku Zasshi 1960,801706-12

合成路线图解说明: The esteritication of nicotinic acid (I) with methanol and HCl or H2SO4 yields the corresponding methyl ester (II), which is treated with ethanolamine (A) to afford N-(beta-hydroxyethyl)nicotinamide (III). Finally, this compound is transformed into the nitrate ester by the usual methods.