【药物名称】Desflurane, I-653, Suprane
化学结构式(Chemical Structure):
参考文献No.9039
标题:2-(Difluoromethoxy)-1,1,1, 2-tetrafluoroethane as an anaesthetic
作者:Terrel, R.C. (BOC, Inc)
来源:EP 0285237
合成路线图解说明:

This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways: 1) With fluorine in argon at -10 C. 2) With KF in diethyl glycon at 195 C. 3) With BrF3 at room temperature.

参考文献No.9843
标题:Process for making fluorinated ethers
作者:Russell, J.P.; Szur, A.J.; Terrell, R.C. (Airco, Inc.)
来源:US 3897502
合成路线图解说明:

This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways: 1) With fluorine in argon at -10 C. 2) With KF in diethyl glycon at 195 C. 3) With BrF3 at room temperature.

参考文献No.69305
标题:Partition coefficients of I-653 in human blood, saline and olive oi
作者:Eger, E.I.
来源:Anesthesia and Analgesia 1987,66(10),971
合成路线图解说明:

This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways: 1) With fluorine in argon at -10 C. 2) With KF in diethyl glycon at 195 C. 3) With BrF3 at room temperature.

参考文献No.85089
标题:I-653
作者:De Angelis, L.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(4),313
合成路线图解说明:

This compound can be obtained by fluorination of isoflurane [2-(difluoromethoxy)-2-chloro-1,1,1-trifluorethane] (II) in three different ways: 1) With fluorine in argon at -10 C. 2) With KF in diethyl glycon at 195 C. 3) With BrF3 at room temperature.

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