MDL-27695-药物合成数据库

【药物名称】MDL-27695

化学结构式(Chemical Structure):

参考文献No.	151172
标题:	MDL 27,695
作者:	Baumann, R.J.; Bitonti, A.J.; Edwards, M.L.
来源:	Drugs Fut 1991,16(10),908

合成路线图解说明: Reaction of 1,7-diaminoheptane with acrylonitrile gives the dinitrile (II). Reduction of the nitrile functionality yields the tetraamine (III). Reductive alkylation gives the dibenzyltetraamine MDL 27,695.

参考文献No.	157716
标题:	Antimalarial polyamine analogs
作者:	Dumont, J.A.; Stemerick, D.M.; Sjoerdsma, A.; McCann, P.P.; Edwards, M.L.; Bitonti, A.J.
来源:	J Med Chem 1991,34(2),569-74

合成路线图解说明: Reaction of 1,7-diaminoheptane with acrylonitrile gives the dinitrile (II). Reduction of the nitrile functionality yields the tetraamine (III). Reductive alkylation gives the dibenzyltetraamine MDL 27,695.