Abbott-49816, A-49816-药物合成数据库

【药物名称】Abbott-49816, A-49816

化学结构式(Chemical Structure):

参考文献No.	77455
标题:	A-49816
作者:	Luther, R.R.; Plattner, J.J.
来源:	Drugs Fut 1988,13(12),1039

合成路线图解说明: Friedel-Crafts acylation of 2,3-dichlorophenetole with 4-methoxybenzoyl chloride gives the substituted benzophenone (I). Selective cleavage of the ethyl ether in (I) with AlCl3 produces phenol (II). Alkylation of (II) with ethyl bromoacetate is followed by heating with 48% HBr to give the phenoxyacetic acid derivative (III). Amidomethylation of (III) using the Tscherniac-Einhorn procedure gives (IV), which affords A-49816 after hydrolysis with HCl/EtOH.

参考文献No.	547124
标题:	[(Aminomethyl)aryloxy]acetic acid esters. A new cl
作者:	Lee, C.-M.; Plattner, J.J.; Ours, C.W.; Horrom, B.W.; Smital, J.R.; Pernet, A.G.; Bunnell, P.R.; El Masry, S.E.; Dodge, P.W.
来源:	J Med Chem 1984,271579

合成路线图解说明: Friedel-Crafts acylation of 2,3-dichlorophenetole with 4-methoxybenzoyl chloride gives the substituted benzophenone (I). Selective cleavage of the ethyl ether in (I) with AlCl3 produces phenol (II). Alkylation of (II) with ethyl bromoacetate is followed by heating with 48% HBr to give the phenoxyacetic acid derivative (III). Amidomethylation of (III) using the Tscherniac-Einhorn procedure gives (IV), which affords A-49816 after hydrolysis with HCl/EtOH.