(R)-Oxaprotiline hydrochloride, Levoprotiline hydrochloride, CGP-12103A-药物合成数据库

【药物名称】(R)-Oxaprotiline hydrochloride, Levoprotiline hydrochloride, CGP-12103A

化学结构式(Chemical Structure):

参考文献No.	9836
标题:	Novel levorotatory basic deriv. of 9, 10-ethaneant
作者:	Storni, A. (Novartis AG)
来源:	EP 0014433; JP 1991271263; US 5004755

合成路线图解说明: Levoprotiline (II) is the levorotatory R-enantiomer of oxaprotitine (I). It is obtained by resolution of oxaprotitine via its (-)-di-O,O'-p-toluoyl-L-tartaric acid salt, which is then cleaved with hydrogen chloride to levoprotiline hydrochloride (CGP-12 103 A). By an analogous procedure, using (+)-di-O,O'-p-toluoyl-D-tartaric acid, the dextrarotatory S-enantiomer, CGP 12 104 A (III), is gained from oxaprotiline.

参考文献No.	72702
标题:	Levoprotiline hydrochloride
作者:	Hauser, K.; Storni, A.; Maitre, L.
来源:	Drugs Fut 1988,13(11),956

合成路线图解说明: Levoprotiline (II) is the levorotatory R-enantiomer of oxaprotitine (I). It is obtained by resolution of oxaprotitine via its (-)-di-O,O'-p-toluoyl-L-tartaric acid salt, which is then cleaved with hydrogen chloride to levoprotiline hydrochloride (CGP-12 103 A). By an analogous procedure, using (+)-di-O,O'-p-toluoyl-D-tartaric acid, the dextrarotatory S-enantiomer, CGP 12 104 A (III), is gained from oxaprotiline.