【药物名称】TEI-6170(free acid), TT-62
化学结构式(Chemical Structure):
参考文献No.5098
标题:5-Fluoro-2'-deoxyuridine derivs. and a process for the preparation thereof
作者:Watanabe, K.; Saito, M.; Kato, Y.; Oba, T.; Fukushima, H.; Hara, T. (Teijin Ltd.)
来源:EP 0081386
合成路线图解说明:

By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.

参考文献No.5099
标题:5-Fluoro-2'-deoxyuridine derivs. and method for their preparation
作者:Watanabe, K.; Kato, Y.; Sato, M.; Oba, T.; Fukushima, H.; Hara, T. (Teijin Ltd.)
来源:JP 1984093096
合成路线图解说明:

By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.

参考文献No.6613
标题:Antiviral agents which active principles are 5-fluoro-2'-deoxyuridine derivs.
作者:Watanabe, K.; Fujinaga, S. (Teijin Ltd.)
来源:JP 1987036322
合成路线图解说明:

By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.

参考文献No.147005
标题:TT-62
作者:Hoshi, A.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1990,15(10),1002
合成路线图解说明:

By condensation of 3'-O-acetyl-5-fluoro-2'-deoxyuridine (I) with tetradecylphosphoric acid (II) by means of tosyl chloride in anhydrous pyridine followed by deacetylation with ammonia and formation of the sodium salt.

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