T-506-药物合成数据库

【药物名称】T-506

化学结构式(Chemical Structure):

参考文献No.	4192
标题:	Novel 5-fluro-2'-desoxyuridine derivs. and their salts, process for their preparation and antitumor compsns. containing them
作者:	Hori, T.; Myokan, I.; Miyabara, S. (Toyama Chemical Co., Ltd.)
来源:	CH 670091; DE 3535766; FR 2571374; GB 2166740; JP 1986091196; JP 1986171498; US 4684631; US 4740503

合成路线图解说明: The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III), which is then condensed with trimethylamine (IV) in toluene.

参考文献No.	127626
标题:	T-506
作者:	Hoshi, A.; Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1990,15(5),467

合成路线图解说明: The reaction of 2'-deoxy-5-fluoro-3'-O-oleoyluridine (I) with 2-bromoethylphosphodichloridate (II) by means of lutidine in THF gives 2'-deoxy-5-fluoro-3'-O-oleoyluridine 5'-(2-bromoethyl)phosphate (III), which is then condensed with trimethylamine (IV) in toluene.