Ro-23-9424/001(monoNa salt, diH2O), Ro-23-9424-药物合成数据库

【药物名称】Ro-23-9424/001(monoNa salt, diH2O), Ro-23-9424

化学结构式(Chemical Structure):

参考文献No.	105284
标题:	Cephalosporin 3'-quinolone esters with a dual mode of action
作者:	Albrecht, H.A.; Beskid, G.; Chan, K.-K.; Christenson, J.G.; Cleeland, R.; Deitcher, K.H.; Georgopapadakou, N.H.; Keith, D.D.; Pruess, D.L.; Sepinwall, J.; et al.
来源:	J Med Chem 1990,33(1),77-86

合成路线图解说明: Displacement of iodide from the protected cephalosporin (I), with the potassium salt of fleroxacin (II) results in joining of the two fragments via an ester bond. Removal of protecting groups with trifluoroacetic acid in nitromethane followed by treatment with hydrochloric acid in acetone/water yields Ro 23-9424.

参考文献No.	140757
标题:	Ro 23-9424
作者:	Christenson, J.G.; Squires, E.
来源:	Drugs Fut 1991,16(7),620

合成路线图解说明: Displacement of iodide from the protected cephalosporin (I), with the potassium salt of fleroxacin (II) results in joining of the two fragments via an ester bond. Removal of protecting groups with trifluoroacetic acid in nitromethane followed by treatment with hydrochloric acid in acetone/water yields Ro 23-9424.